[Case Study 1, Screen 1.] For each finding, indicate whether it localizes the source of infection or indicates sepsis-related organ dysfunction or hypoperfusion. Each row has one answer. Grid columns: Localizes the source of infection | Indicates organ dysfunction or hypoperfusion.

CLIENT
63-year-old woman. Weight 70 kg.
History: type 2 diabetes (takes metformin), hypertension (takes lisinopril).
Lives with spouse; independent in all activities; baseline fully oriented.
Home blood pressure readings usually about 132/78 mm Hg.

NURSES' NOTES - 0800
Spouse reports the client has been "sleepy and confused" since last night.
Client reports burning on urination for 3 days and has been eating and
drinking very little for 2 days. Oriented to person only. Skin warm and
flushed; mucous membranes dry. Reports right flank pain, 5/10. Lungs clear
bilaterally. Capillary refill 3 seconds. Last voided a small amount of dark
urine early this morning.

VITAL SIGNS - 0800
Temperature      39.0°C (102.2°F)
Heart rate       116/min
Respiratory rate 24/min
Blood pressure   88/50 mm Hg (MAP 63 mm Hg)
SpO2             95% on room air

LABORATORY RESULTS - 0815            Result            Reference range
WBC                                  18,600/mm³        5,000-10,000/mm³
  Bands                              14%               0-5%
Lactate                              4.1 mmol/L        0.5-2.0 mmol/L
Creatinine                           1.9 mg/dL         0.5-1.1 mg/dL
  (baseline 1 month ago: 0.9 mg/dL)
BUN                                  40 mg/dL          7-20 mg/dL
Glucose (random)                     238 mg/dL         70-140 mg/dL
Sodium                               137 mEq/L         135-145 mEq/L
Potassium                            4.6 mEq/L         3.5-5.0 mEq/L
Platelets                            172,000/mm³       150,000-400,000/mm³
Urinalysis: cloudy; nitrite positive; leukocyte esterase positive;
            WBC more than 50/hpf

Localizes the source of infection | Indicates organ dysfunction or hypoperfusion

1. ANew confusion (oriented to person only)
2. BBurning on urination for 3 days
3. CCreatinine 1.9 mg/dL (baseline 0.9 mg/dL)
4. DLactate 4.1 mmol/L
5. ECloudy, nitrite-positive urine with more than 50 WBC/hpf
6. FRight flank pain